Monday, April 11, 2011

Recovering damaged or corrupted DOCX Word 2007 documents

If you've used Microsoft Word enough in your lifetime you've likely encountered a document that was fine yesterday only to find out today it's completely trashed. Word documents, more than any other binary file type in my experience, have a propensity to become corrupt and generally unreadable to the user. Rarely can the cause of the corruption be identified but some theorize that modifying the document with many different versions of Word, even though they are all supposedly compatible, uncovers the potential problem. This theory carries some weight because different versions of Word often handle a corrupt document in different manners. For example, a corrupt document may cause one version of Word to crash open opening of it, while another will display a mixture of text and binary characters. Nevertheless, the contents of the document are not easily usable which, needless to say, can be quite devastating if the document is of any importance and the backup is non-existent.

In such situations of damaged and corrupted documents, the user has just a few options. One option is to attempt to recover portions of the text contained in the document by opening it in Notepad. This process is often tedious because you are forced to filter through portions of garbage to pull out the relevant bits. Secondarily, this is not something recommended for lengthy documents � again, because of the extra formatting contained in a typical Word document must be parsed.

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Another option is leveraging the free Windows application Damaged-DOCX2TXT. At its simplest explanation, Damaged-DOCX2TXT somewhat automates the process a user would be forced to undertake using the Notepad situation above. The interface is minimalistic with just a typical File->Open where you pass the file that you want recovered. After processing, you are presented with just the text of your document � the initial formatting and fonts will be unfortunately lost. With the plain-text in hand, it can be copy and pasted into Word where all the extra flair can be reapplied.

While Damaged-DOCX2TXT isn't a miracle worker, sometimes the recovering of the actual text content is sufficient when previously you felt all was lost. One other limitation of the portable software is its requirement that the initial Word document be in the Word 2007+ .docx file type. However, this software is free, and might save a lot of time in some cases.

Damaged DOCX2TXT requires the Microsoft .Net version 2 framework. Using a GUI front end and a Perl coded back end, Damaged DOCX2TXT will extract the text even from damaged or corrupted Word 2007 docx files where Word 2007 itself fails to salvage text. It can also be simply used as a viewer of the text in a docx file without having Word 2007.


Reviewed by HowInTheTech

Direct Download: http://ping.fm/oduZR



Saturday, April 9, 2011

Short Selling Strategy: Risks and Rewards

The conventional view for the longest time was that the surest way to make money in stocks was to buy and hold them for the long-term. Anyone who thought otherwise was called a speculator, trader or momentum player. It was alleged that "buy and hold" investors were sure-fire winners. But after 2000-2002 bear market, the view of the Investment market changed, hardly anyone believes that "buy and hold" investors are sure winner.

The most widely published evidence that buying and holding is not the best way to make money in stocks was presented in an article printed September 27, 2002 in USA Today. It featured a chart showing the up and down movements of the Dow Jones Industrial Average from 1966 through 1982. The point of the article was that the Dow opened 1966 at 983.51 and closed 1982 at 991.72. Up 8.21 points, less than one-percent, in 17 years!

The USA Today article, Timing is Everything When Stocks Stall showed that there were six bull markets and five bear markets during this period of time. Had you bought the Dow at the beginning of each bull market and gone into cash at the beginning of each bear market, you would have gained 549%. Had you ridden the Dow up in each bull market and sold it short in each bear market, you would have gained 2,680%.

This example clearly shows that buying long in bull markets and selling short in bear markets is a much better strategy than buying and holding stocks for the long-term. So why does the conventional wisdom on Wall Street teach us that "buy and hold" is the best investment strategy? Why does it tell us you can't "time the market," and warn us against selling-stocks short?

The reason is obvious: The Wall Street brokerage houses and mutual funds want to control your money at all times. Selling stocks when prices go down is very bad for business. Not only does it reduce the assets from which they make money, but it drives stock prices lower which makes them look bad.

Brokers tell you to buy, buy, buy because they don't want to offend the companies they represent. They say you can't time the market because it supports the argument of staying long all the time. They are against selling short because it rubs their customers the wrong way. Incidentally, you are not their customer. You are the victim of their clever marketing schemes.

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What is Short Selling?

Have you ever been absolutely sure that a stock was going to decline and wanted to profit from its regrettable demise? Wouldn't it be nice to see your portfolio increase in value during a bear market? Both scenarios are possible. Many investors make money on a decline in an individual stock or during a bear market, thanks to an advanced investing technique called Short Selling.

Short selling is a trading strategy, which is neither terribly complex nor entirely simple. In other words, it's a concept that many investors have trouble understanding. In general, people think of investing as buying an asset, holding it while it appreciates in value, and then eventually selling to make a profit. When an investor goes long on an investment, it means she has bought a stock believing its price will rise in the future.

Conversely, when an investor goes short, he is anticipating a decrease in share price. Investor makes money only when a shorted security falls in value.

Sounds good, but selling stocks short involves selling something you don't own. Somehow this has a bad ring to it. How can you sell something you don't own? Don't worry about it. It's done every day. For example, you subscribed to an investment newsletter. The publishing company did not have next month's issue printed when they took your order. So they actually sold next month's issue of the newsletter short.

Now the publisher has the responsibility of putting the newsletter together and delivering it to you as promised. You expect that they will because they have done it over and over before, but you have taken a risk.

The publishing company also took a risk in accepting your order. They have to get the newsletter to you at a profit. Otherwise they eventually will go broke. In summary, you took a risk in buying something the provider didn't have. The provider took a risk in delivering it at a profit. Most businesses are run this way. So selling short is NOT a bad thing.

Short selling is the selling of a stock that the seller doesn't own. More specifically, a short sale is the sale of a security that isn't owned by the seller, but that is promised to be delivered. That may sound confusing, but it's actually a simple concept.

Here is how it works

When you short sell a stock, your broker will lend it to you. The stock will come from the brokerage's own inventory, from another one of the firm's customers, or from another brokerage firm. The shares are sold and the proceeds are credited to your account.

Sooner or later you must "close" the short by buying back the same number of shares (called covering) and returning them to your broker. If the price drops, you can buy back the stock at the lower price and make a profit on the difference. If the price of the stock rises, you have to buy it back at the higher price, and you lose money.

The selling of a security that the seller does not own is called a short sale. Short sellers assume that they will be able to buy the stock at a lower amount than the price at which they sold short.

Short Selling is a trading strategy with many unique risks and pitfalls. Novice investors are advised to avoid short sales.

A market transaction in which an investor sells borrowed securities in anticipation of a price decline and is required to return an equal number of shares at some point in the future. The profit that the investor receives is equal to the value of the sold borrowed shares less the cost of repurchasing the borrowed shares.

Suppose 1,000 shares are short sold by an investor at $25 apiece and $25,000 is then put into that investor's account. Let's say the shares fall to $20 and the investor closes out the position. To close out the position, the investor will need to purchase 1,000 shares at $20 each ($20,000). The investor captures the difference between the amount that he or she receives from the short sale and the amount that was paid to close the position, or $5,000.

Most of the time, you can hold a short for as long as you want. However, you can be forced to cover if the lender wants back the stock you borrowed. Brokerages can't sell what they don't have, and so yours will either have to come up with new shares to borrow, or you'll have to cover. This is known as "Being Called Away". It doesn't happen often, but is possible if many investors are selling a particular security short.

Since you don't own the stock (you borrowed and then sold it), you must pay the lender of the stock any dividends or rights declared during the course of the loan. If the stock splits during the course of your short, you'll owe twice the number of shares at half the price.

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There are two main motivations to Short Sell a Stock :

1. To Speculate

The most obvious reason to short is to profit from an overpriced stock or market. Probably the most famous example of this was when George Soros "broke the Bank of England" in 1992. He risked $10 billion that the British pound would fall and he was right. The following night, Soros made $1 billion from the trade. His profit eventually reached almost $2 billion.

2. To Hedge

For particular reasons, very few sophisticated money managers use short selling as an active investing strategy (unlike Soros). The majority of investors use shorts to hedge. This means they are protecting other long positions with offsetting short positions.

There are some restrictions on the size, price and types of stocks you are able to short sell. For example, many brokers impose large margin requirements on clients who short stocks with a market price that is less than $5.

Before July 2007, the Securities and Exchange Commission had "Up-tick Rule (also termed as zero plus tick rule)". This rule required that every short sale transaction be entered at a higher price than that of the previous trade and kept short sellers from adding to the downward momentum of an asset when it was already experiencing sharp declines. This rule is now eliminated.

The whole idea of selling stocks short is to make money from stocks that are going down in price. It's the exact opposite of buying stocks long expecting that they will go up in price. In selling short, you sell stocks that appear to be high in price and buy them back at lower prices.

For example, let's suppose ABC is trading at $30 per share. You think it could go down to a lower price. So you call your broker and say, "I want to sell 100 shares of XYZ at $30 per share or higher to open." You can make transaction on most of the online brokerages which will have a check box that says "short sale."

Clearly, short selling can be profitable. But then, there's no guarantee that the price of a stock will go the way you want (just as with buying long). You can think of the outcome of a short sale as basically the opposite of a regular buy transaction.

Short selling is another technique you can add to your trading toolbox. That is, if it fits with your risk tolerance and investing style. Short selling provides a sizable opportunity with a hefty monkey of risk on its back.

You need to have a margin account in order to sell stocks short. A margin account allows the broker to extend credit to you in accordance with Federal Regulation T of the Federal Reserve Board. If you do have a margin account and you place an order to sell short, the broker will check to see if you have sufficient cash in your account to satisfy Reg T.

This means that you must have at least 50% of the amount involved in short-selling the stock in your account as cash. This cash shows that you have sufficient funds available to buy the stock back should it go against you.

Once the broker verifies that you have sufficient cash in your account to make the trade, he or she will borrow the requested shares of stock, and credit your account for the amount received from selling the stock.

For Example, In the case of selling short 100 shares of ABC at $30, you would need to have half or $1500 cash in your account and you would receive a credit of $3000 less commissions. Overall, you would have a credit balance of $4500 in your account.

Can you go out and spend this money? Not on your life. At least not until the price of the stock starts going down. Let's suppose ABC goes to $20 per share. You've made $1000. Your credit balance is still $4500, but the market value of the stock is only $2000. So your equity is $2500, ($4500 - $2000). Although your paper profit is $1000, but your buying power is now $2500. This is the amount you can spend to buy stocks long or sell stocks short.

Although you will always pay interest on money you borrow from the broker, most brokerage houses do not pay interest on the proceeds of short sales. You may, however, be able to negotiate an interest payment if you have a sizeable account. You will also be charged by the broker for any cash or stock dividend payments on your short positions.

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How to Manage Risk on Short Sale?

The potentially unlimited loss associated with a short sale makes it important to proactively manage the risk.

Just as a sell-stop or trailing sell-stop orders can help control losses on a long purchase, a buy-stop or trailing buy-stop order can help to manage loss on a short sale, in case the stock price goes up.

For a short sale, buy-stop orders trigger a market order to buy back when the ask price is equal to, or greater than, the stop price entered.

A trailing buy-stop involves an entered dollar or percentage amount above the current market. If the ask price only moves upward (against you), the trailing stop will track the ask price until it reaches or surpasses your entered trailing amount. However, unlike the standard buy-stop order, when the price moves downward (in your favor), a trailing buy-stop will readjust the trigger price from the new low ask price reached.

Questions to Ask Yourself Before Short Selling Stocks

Before you even began to sell stocks short there are a couple questions that you should ask yourself. Don't start thinking about "how to short a stock and make big bucks" until you can say yes to these questions.
1. Am I Eligible to Short Stocks? Is my trading account not for long only trades?
2. Do I have Any Experience with Short Term Trading?
3. Am I comfortable with Short Term Trading?
4. Do I have a Plan, a reason to short a stock?

Illegal Short Selling

As of 2009 Naked Short Selling is illegal. This is simply selling a stock without having something to back it up with (like a borrowed stock). Your broker should take care of this, so you don't have to worry about breaking a law.

What it does mean for you, is that you can only short stocks that your broker has available. So make sure if you are going to short a stock that your broker has some of it in reserve, otherwise your order will not get filled.


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Friday, April 8, 2011

Spiritual Causes of Depression through Eyes of Christians

"Spiritual" causes of depression are in some ways as speculative as psychological or even physiological explanations. Just as there are currently no way to exactly measure brain chemistry, there are no ways for us to "see" all of what is happening spiritually within a person. Many of the spiritual causes of depression are essentially refined or redefined versions of psychological causes. For example, instead of talking about behavior, Christians talk about sin. In the area of cognition Christians emphasize not only one's faulty view of oneself, but also a faulty view of God and his character. Finally, while secular psychology recognizes a distinction between body and mind, Christians should have a proper understanding of both the distinctions and interrelations between the human body and soul.

The Biblical point of view

What does the Bible say about depression? Little or nothing! It provides no support to those who become truly depressed from whatever cause. Paul went through terrible trials (2 Cor. 11:22-30) yet there is not a glimmer of depression in his letters. Indeed Paul instructs Christians to "Rejoice always in the Lord" (Philip.4:4), and so important is this that he repeats it "Again I say rejoice"! Two verses later again he instructs "Be anxious for nothing". Only a few verses further on he gives clear directives for the sound Christian life; "Whatsoever things are true, whatsoever things are noble...if there is any virtue, and if there is anything praiseworthy, think on these things."

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Thus the Christian is instructed to have a very positive mind set. Therefore, is it not obvious that the Christian who sinks into despair and despondency for whatever cause is actually disobeying the Bible's clear requirements. He is NOT fixing his eyes upon Jesus and the glorious hope of the future that is a continual refrain in the Bible. Read Philip. 4:4-13 and check if those who are depressed are obeying God's word to mankind.

There is also little about depression in the Old Testament. Asaph was despondent when he saw the lives of the rich until he went into the House of the Lord! There he took a step back from his personal viewpoint and saw it all from God's long term plan - and his heart was lifted (Ps. 73:1-17).

David was persecuted by King Saul and felt low at times. But on one such time, he asks "Why are you cast down, O my soul?" (Psalm 42:5) Notice that this is a question, implying that the heart had no business in being cast down. He then gives his heart the very positive instruction "Hope in God.." Thus, his reaction to depression was exactly the same as Asaph's - a drawing back from his own little viewpoint and looking towards God and seeing life from His perspective. What may seem to be an exception, in Ps. 6:6 David calls upon the Lord to rebuke his troublesome enemies. But this is not the usual long term depression. David was a fighter against great odds and he knew the Lord was with him.

So, while very few episodes in Bible are clearly identified as depression, there are plenty of others, more inferred based on their responses to situations. Jeremiah, in the book of Lamentations, expresses deep pain and agony of the soul: "Is it nothing to you, all you who pass by? Look and see if there is any sorrow like my sorrow, which was brought upon me" (Lam. 1:12). One of the most familiar passages is Psalm 42-43.  Psalm 42 begins with, "As the deer pants for the water brooks, so my soul pants for You, O God" (42:1), and continues with:
"Why are you in despair, O my soul?
And why have you become disturbed within me?

O my God, my soul is in despair within me" (Psalm 42:5-6)

The phrase "Why are you in despair, O my soul?" is repeated at the end of Psalm 42 and again in Psalm 43. Some authors have also suggested that Job, Saul, Elijah and even Jesus in the desert showed signs of depression.

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Depression can be more difficult to deal with in Christian circles because the expectations for "life and life abundant" is much higher and because of emotional ties particular theological positions. Just as scientists have biases toward exclusively physiological explanations of depression and psychologists towards exclusively psychological explanations, Christians often gravitate toward interpreting all events in spiritual terms. While it is true that "our battle is not against flesh and blood," Christians should also keep in mind that the physical world is real and that simple explanations are often incomplete.

Christian Thinking

Admitted many theological and biblical discussions have little or no bearing on one's life. But in the area of depression, the Christian's thought life plays a major role. The cognitive theory of depression in psychology has done much to help explain the significance of many of Paul's charges such as "taking every thought captive" (2 Cor. 10:5), "if there is anything excellent or praiseworthy � think about such things" (Phil. 4:9), and to have the mind of Christ (1 Cor. 2:16).

The two most common areas of faulty Christian thinking are one's view of oneself and one's view of God. The generalizing events are often applied to specifically Christian ideas such as, "I sinned in area X, therefore I must be an evil person, unworthy of God." False doctrine, especially in the area of salvation, may also play a critical role. If one incorrectly believes that is possible to lose one's salvation, he or she may experience depression from anxiety.

Many Christians also develop faulty views of God which can result in depression. Often Christian's project onto God their own false expectations of themselves or false expectations placed upon them by parents or teachers. In his discussion of Psalm 13:1-6, Neil Anderson says, "Even though he believes in God, David is depressed because what he believes about God is not true. How can an omnipotent and omniscient God forget about David for even one minute, much less forever?"  Depressed people also tend to feel abandoned by God, characterized by David's words, "My God, my God, why have you forsaken me?" (Ps. 22:1). "Does God abandon God's people? No. Do people with depression feel that God has abandoned them? Yes?"

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Sin and Depression

No other cause of depression should be as carefully discussed as that of sin. Unfortunately, the stigma in society at large surrounding mental illnesses is heightened rather than lessened in the Christian discussion. But at the same time, sin is very real and very harmful. Often depressed people are characterized by irrational guilt and shame, yet those that fail to deal with habitual sin often fall further and further into depression.

Consider the following statement, "Compassion cannot ignore unbelief or son. Too often, family and friends think the depressed person is very fragile and cannot handle any frank discussion about sin or hard-heartedness. But to ignore these issues when they are obvious in someone's life is to treat that person without love or compassion." Some might consider this approach too harsh, while others might consider it too soft. Either way, assuming that sin alone is the cause and cure of depression is probably no more helpful than assuming that medical treatments alone can cure depression. But ignoring sin is equally unhelpful.

Spiritual Warfare

 In C.S. Lewis's The Screwtape Letters, an elder demon Screwtape writes lessons to his nephew Wormwood on how to cause the most damage to his human "student." Screwtape suggests to Wormwood that his most successful course of action is either to cause his student to think about demons and the spiritual realm so much that it causes him to obsess and fear it or to ensure that his student never thinks about spiritual things and remains woefully ignorant on the matter. While it is true that those who do emphasize demonic activity often go to extremes, others tend to react too strongly against such overemphasis and ignore or downplay the reality of spiritual realm and its affects on our lives. As is true elsewhere, a balanced approach is vital.

Biblically, there is a good deal of support for the idea that demons can cause mental and spiritual depression. Job experienced severe ailments, both physical and spiritual, and it is very clear that God allowed Satan to directly cause the problems. Saul was tormented by "a demon sent from God" (1 Sam. 19:19). Jesus cast demons out of many people during his ministry on earth. Even Paul was sent a "messenger from Satan" (2 Cor. 12:7).

Similar to any of the other causes of depression, spiritual warfare may or may not play a role in a particular individual's depression. And if it does play a role, it is probably one of several factors that should be considered.

How should a Christian treat depression?

Christians tend to look for the real cause of depression in themselves, not relying entirely on the theoretical medical causes proposed by psychiatrists/psychologists. There are some stages of depression that are considered common to all cases.
  1. The person records the progress of his "illness" in some detail, from childhood to recovery.
  2. They are told by their doctor/psychiatrist that they are "ill" with depression.
  3. This is attributed to "a chemical imbalance" - usually serotonin.
  4. They express their great gratitude and relief for this "discovery" as they can now offload their sense of guilt for their condition and can blame something over which they can have no control and therefore cannot be held responsible for: They have got an "illness".
  5. They are prescribed drugs that lift their mood.
  6. However, they still realize that there is something not right, and begin to take positive steps to get back to normal.
  7. Eventually they are well on their way to becoming normal people - with or without the drugs.
  8. At the end they understand the certain attitudes to life that are far from normal and that might lead to the illness on the first place - attention seeking, excessive fear of what others are thinking of them, perfectionism, etc. Some admit that they were mainly to blame for their depression.
  9. They realize that they are now a much stronger person than they were before their depression.
  10. Most admit that they were glad they had gone through their experience because they had learnt so much more about themselves and now had a changed, more relaxed, attitude to life.

So, how should the Christian deal with his depression?
  1. If the root problem is self-centeredness, then the answer is obvious; he must begin to take a real interest in other people and their circumstances. This must be a genuine interest, and not one that is seeking to obtain their approval. There are many passages in the Bible that tell us to put others before ourselves (Eph. 2:3-4, Heb.12:11-14.)
  2. The Bible never says that life - Christian or otherwise - will be smooth and trouble free. When we realize this, we must stand up to the problems of life, no matter how big they may be. They are sent to strengthen us and test how strong our Christian faith truly is (James 1:2-4). For the Christian, he should never forget that no matter how bad the circumstances may seem to him, he must never ever forget that ultimately, God is in complete control of all events. Whatever happens, he must never run away from the problem(s) but must deal with them in a mature Christian way; no other attitude is honoring to God.
  3. Any tendency to mope and have a "pity party" must be firmly resisted. An active, loving and outgoing life must be maintained - irrespective of how we feel.
  4. Realize that you can't base life on your emotions. Christians base life on truth, not emotions. Philippians 4:1 commands us to rejoice (whether we feel like it or not!). And James 1:2 asks us to "Consider it all joy when we fall into various trials." Notice that James doesn't tell us to feel joyful; he tells us to reckon, to choose to think about your situation as a spot where you can have joy. This question of feelings is very important. The Bible never tells us to do the right thing "if and when we feel like doing it." It is very clear indeed that we must do good things for others whether we feel like doing them or not. This includes doing the mundane things we all have to do at times. Let us do them all to the glory of God. You can be absolutely sure that the good feelings will come in due time once you have trained yourself to do what is right in the first place. This can take six weeks to retrain the autonomic nervous system so that we have a better set of habits that become part of us.
  5. Heed God's Advice. However, many people talk about "faith" and only mean a vague hope that God will somehow pull them through. That's too nebulous a concept to be reliable. Many of the same people who claim to have faith keep plunging through life ignoring God's principles for healthy living. If we spurn the good advice that the Bible contains, we won't escape the consequences - even if we have faith.
  6. There is one physical thing that can be done that is far more effective than any medication. Tests have shown the very positive benefits of doing regular (fairly hard) exercise! This gets the whole body working more normally. It lifts depression and if it is followed by a warm shower, then the resulting glow over the whole body gives a further uplift and positive sense of well-being.

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Thursday, April 7, 2011

Clinical Depression as Risk Factor for Alzheimer's Disease

Overview

Clinical Depression and Alzheimer's disease have a lot in common and share a complex relationship. Depression -- a mental disorder caused by chemical imbalances in the brain -- can include symptoms that look like Alzheimer's, such as concentration problems, memory impairment, and difficulty making decisions. When depression looks like Alzheimer's disease or another dementia, it's often referred to as pseudodementia. It's treatable, but relapse is a significant concern. Depression and Alzheimer's disease can also occur together, where each disorder requires treatment that doesn't interfere with the treatment of the other condition. This is another complex diagnostic and treatment situation.

Traditional science admits that Depression is one of the multiple symptoms, associated with Alzheimer's Disease (AD). However, new research data show a different causal relationship between these two disorders. Clinical depression might be a substantial risk factor for AD.

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Study from Rush University Medical Center (2008)

Investigators from Rush University Medical Center sought to determine if depressive symptoms actually contribute to the development of dementia (risk factor hypothesis) or are a consequence of the disease (reverse causality hypothesis.) The research emanates from numerous observational studies that show higher levels of depressive symptoms in old age are associated with increased incidence of Alzheimer's disease and mild cognitive impairment.

Robert S. Wilson, PhD, a neuropsychologist at the Rush Alzheimer's Disease Center, and colleagues examined data from the Rush Religious Orders Study, a cohort of 917 older Catholic clergy without dementia at study onset, to examine the change in depressive symptoms of Alzheimer's disease before and after the emergence of the cognitive symptoms of the disease.

For up to 13 years, the study participants underwent annual clinical evaluations that included assessment of depressive symptoms, cognitive testing, and clinical classification of mild cognitive impairment (MCI) and Alzheimer's disease. During the study period, 190 participants developed Alzheimer's disease.

Consistent with earlier findings in the Rush Religious Orders Study, having more depressive symptoms at baseline was associated with increased incidence of Alzheimer's disease and MCI.

However, the study found that those who developed Alzheimer's disease showed no increase in depressive symptoms before clinical diagnosis. Researchers were able to observe patients during a mean of approximately four years before the onset of dementia. Additionally, researchers saw no increase in depression during the three to four years preceding the onset of MCI, which antedates the onset of dementia by several years.

"If depressive symptoms are a consequence of dementia or a reaction to declining function, depressive symptoms would likely increase at some point before dementia is clinically evident," said Wilson. "We observed no such increase."

The study also found that even after the diagnosis of Alzheimer's disease was made there was no general increase in depression, but rather an increase that was confined to individuals with certain personality traits.

"Depressive symptoms may be associated with distinctive changes in the brain that somehow reduce neural reserve, which is the brain's ability to tolerate the pathology associated with Alzheimer's disease," said Wilson.

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Study from University of Massachusetts Medical School (2010)

The study, headed by epidemiologist Jane Saczynski of the University of Massachusetts Medical School, used data from the famous Framingham Heart Study to track depression and dementia in 949 people over 17 years.

At the beginning of the study, none of the participants had any dementia symptoms; by the end, 136 had developed Alzheimer's and 28 had other dementias. Of those who had depressive symptoms at the beginning of the study, 21.6 percent later developed dementia, compared with 16.6 percent of non-depressed individuals. After controlling for factors like smoking and genetics, the researchers found that depression raised the risk of later dementia by 50 percent.

The long time frame makes it less likely that the participants already had dementia-related damage at the beginning of the study, Saczynski said. And because the depression showed up so much earlier than the dementia, the study, like Wilson's, supports the notion of depression as a dementia risk factor, not a symptom.

Exactly how a mood disorder like depression can contribute to Alzheimer's disease isn't currently clear, but the effect is probably cumulative.

One theory, Saczynski said, is that depression weakens the body's defenses against dementia by affecting the brain's blood supply. Cardiovascular disease (another risk factor for Alzheimer's) and depression are often clinically linked, Saczynski said, perhaps because of reduced blood flow to the brain. These vascular changes might render the brain more vulnerable to Alzheimer's-related damage. Another possibility is that the chronic stress of depression changes the brain's structure.

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Study from Erasmus Medical Center (2008)

Dr. Breteler published her study in the April 2008 issue of Neurology when she worked at the Erasmus Medical Center in the city of Rotterdam in the Netherlands. During the study she followed 503 non-demented persons aged 60-90 over a period of 6 years to chart the association, if any, between depression, the development of Alzheimer's disease and hippocompal volume. She used three-dimensional MRI scans to quantify the size of each study participant's hippocampus. Prior to the study 88 participants developed depression before age 60 and 46 participants developed depression after age 60. None of these people showed hippocampal atrophy (i.e. shrinkage of the hippocampus) at the outset of the study.

During the course of the study 33 people developed Alzheimer's disease. Statistical analysis showed that people with a history of early onset depression (before age 60) had a 3.76 times greater chance of developing Alzheimer's than non-depressed participants, whereas people with late onset depression (after age 60) had an increased risk of 2.34 over non-depressed participants. People who developed depression during the study showed no increased risk of developing Alzheimer's.

Dr. Breteler concluded that depression is clearly a predictor of Alzheimer's disease but not necessarily a cause and it's possible there is a single as-yet-unknown mechanism in the brain which causes both problems. Dr. Breteler said that if Dr. Wilson's theory that depression shrinks the hippocampus before onset of Alzheimer's was correct she would have expected to find decreased hippocampal volume in the depressed patients at the study outset, but she didn't find this, since the study participants all had hippocampal volume within normal range. She also said that if depression causes Alzheimer's the people who first experienced depression during the study should have higher rates of Alzheimer's than the normal population. 

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Conclusion

So, who is right: Dr. Wilson and Dr. Saczynski, claiming that depression constitutes a big risk for the AD development later in life, or Dr. Breteler, who did not find this causal relationship? It is probably subject for additional research and multiple longitude studies. However, one thing is obvious. If you have depression � do not let it be. Seek for medical assistance promptly and fight with it by all available means. Not only you make your life miserable, but you also may step forward towards the greater risk of developing AD.


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Wednesday, April 6, 2011

52 Free Alternatives to the Windows Explorer

A file manager is a computer program, supplying a user interface to the files related operations. The most common operations on files are create, open, edit, view, print, play, rename, move, copy, delete, attributes, properties, search/find, and permissions. Some file managers provide network connectivity. This is achieved either by allowing the user to browse for a server, connect to it and access the server's file system like a local file system, or by providing its own full client implementations for file server protocols.

From the very beginning, Windows had the build-in file manager. The first File Manager program bundled with releases of Microsoft Windows between 1990 and 1999. It was intended to be a single instance graphical interface, replacing the line commands of MS-DOS to manage the user's files at the time. File Manager was retired in favor of Windows Explorer with the release of Windows 95 and Windows NT 4.0.

While other components of Windows have experienced multiple, mostly positive, changes, Windows Explorer functionality has left almost intact. It is so basic that the software market is full of competing freeware and shareware utilities, offering better performances and functionality to replace it. Some of the utilities are portable, and do not require installation on the Hard Drive, working successfully from USB thumb drive or slave drive.

I would lie to present a Rating List of the 52 Free File Managers that can successfully replace the lagging Windows Explorer. They all offer different sets of features and graphic user interface. Trying to find that one which better suits your needs, just make a mental inventory and list the features you would like to see in your "dream" file manager. Than review descriptions and pick one that fits your description the best. All utilities are provided with brief description, review, and downloading links.

Access the List: http://ping.fm/NyQep